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Среда, 02 августа 2017

Редакция КНФ сообщила о снятии с публикации и изменении кода АТХ некоторых ЛС

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knf-2017-1Редакция Казахстанского Национального Формуляра сообщила, о снятии с публикации лекарственных средств с истекшим сроком государственной регистрации на территории Республики Казахстан, а также об изменении АТХ-кода некоторых лекарственных средств, согласно обновлению Центра сотрудничества ВОЗ по методологии статистики лекарственных средств (WHO Collaborating Centre for Drug Statistics Methodology https://www.whocc.no/…/updates_in…/atc_ddd_alterations_2017).

ATC/DDD alterations 2017

New ATC codes 2017
New DDDs 2017

ATC alterations

Previous ATC code

ATC level name

New ATC code

A10BX04

exenatide

A10BJ01

A10BX07

liraglutide

A10BJ02

A10BX09

dapagliflozin

A10BK01

A10BX10

lixisenatide

A10BJ03

A10BX11

canagliflozin

A10BK02

A10BX12

empagliflozin

A10BK03

A10BX13

albiglutide

A10BJ04

A10BX14

dulaglutide

A10BJ05

B02BD09

nonacog alfa

B02BD04 1)

B02BD12

trenonacog alfa

B02BD04 1)

L01BA01

methotrexate

L04AX03 2)

L04AC06

mepolizumab

R03DX09

R05CB12

tiopronin

G04BX16

Existing ATC code B02BD04 coagulation factor IX 
Splitting of ATC code. Only the classification of pre-filled syringe/pen of methotrexate for use in non-cancer indications is changed. These products will be moved to the existing ATC code for oral administered product of methotrexate. Parenteral preparations used for treatment of cancer will remain in L01BA01.Other ATC alterations

ATC code

Previous ATC level name

New ATC level name or new ATC level

A10BJ

Glucagon-like peptide-1 (GLP-1) analogues

A10BK

Sodium-glucose co-transporter 2 (SGLT2) inhibitors

C07FX

Beta blocking agents, other combinations

N02AJ 1)

Opioids in combination with non-opioid analgesics

C07AA57

sotalol, combinations

C07FX02

sotalol and acetylsalicylic acid

C07AB52

metoprolol, combinations

C07FX03

metoprolol and acetylsalicylic acid

C07AB57

bisoprolol, combinations

C07FX04

bisoprolol and acetylsalicylic acid

C07F

Beta blocking agents and other antihypertensives

C07F

Beta blocking agents, other combinations

C07FA

Beta blocking agents, non-selective, and other antihypertensives

Deleted

C07FA05

propranolol and other antihypertensives

C07FX01

propranolol and other combinations

C07FB

Beta blocking agents, selective, and other antihypertensives

C07FB

Beta blocking agents and calcium channel blockers

C07FB02 2)

metoprolol and other antihypertensives

C07FB02
C07FB13

metoprolol and felodipine 3)
metoprolol and amlodipine

C07FB03

atenolol and other antihypertensives

C07FB03

atenolol and nifedipine

C07FB07

bisoprolol and other antihypertensives

C07FB07

bisoprolol and amlodipine

C07FB12

nebivolol and other antihypertensives

C07FB12

nebivolo and amlodipine

M01AE51 1)

Ibuprofen, combinations

N02AJ03

N02AJ08

dihydrocodeine and other non-opioid analgesics
codeine and ibuprofen

N02AA55 1)

oxycodone, combinations

N02AA55
N02AJ17
N02AJ18
N02AJ19

oxycodone and naloxone
oxycodone and paracetamol
oxycodone and acetylsalicylic acid 
oxycodone and ibuprofen

N02AA58 1)

dihydrocodeine, combinations

N02AJ01
N02AJ02

N02AJ03

dihydrocodeine and paracetamol 
dihydrocodeine and acetylsalicylic acid 
dihydrocodeine and other non-opioid analgesics

N02AA59 1)

codeine, combinations excl. psycholeptics

N02AJ06
N02AJ07
N02AJ08
N02AJ09

codeine and paracetamol
codeine and acetylsalicylic acid 
codeine and ibuprofen
codeine and other non-opioid analgesics

N02AX52

tramadol, combinations

N02AJ13
N02AJ14
N02AJ15

tramadol and paracetamol
tramadol and dexketoprofen
tramadol and other non-opioid analgesics

N02BA51 1)

acetylsalicylic acid, combinations excl. psycholeptics

N02AJ02

N02AJ07
N02AJ18

dihydrocodeine and acetylsalicylic acid 
codeine and acetylsalicylic acid 
oxycodone and acetylsalicylic acid

N02BE51 1)

paracetamol, combinations excl. psycholeptics

N02AJ01
N02AJ06
N02AJ09

N02AJ17

dihydrocodeine and paracetamol
codeine and paracetamol
codeine and other non-opioid analgesics
oxycodone and paracetamol

Splitting of ATC codes according to contents of the different fixed combinations of opioids and other analgesics. The ATC codes in N02A, N02BA51, N02BE51 and M01AE51 will be maintained for other combinations. Combinations with opioids and non-opioid analgesics currently classified in the following ATC codes N02AA55, N02AA58, N02AA59 will be moved to the new ATC 4th level N02AJ. All the existing combination codes will be kept in N02A since there may be other combinations without analgesics available (e.g. oxycodone and naloxone will remain in N02AA55). The ATC classification of all low dose (<20 mg dose) combinations products of codeine or dihydrocodeine currently classified in N02B or M01A will be altered to the new ATC codes in N02AJ. 
Splitting of ATC code in connection with alterations in C07FX. 
Unchanged ATC code, ATC level name changed.DDD alterations

ATC code

ATC level name

Previous DDD

New DDD

A16AX01

thioctic acid

0.2

g O,P

0.6

g O,P

B02BD

Blood coagulation factors

1)

deleted 1)

G03XB01

mifepristone

0.6

g O

0.2

g O

J01CR01

ampicillin and enzyme inhibitor

2

2) P

6

2) P

J02AC04

posaconazole

0.8

g O

0.3

g O

R03BB04

tiotropium bromide

18

mcg 3) Inhal.powder

10

mcg 3) Inhal.powder

V03AE07

calcium acetate

2

g O

6

g O

DDDs for the various blood coagulation factors in all ATC 5th level codes in B02BD are deleted. No new DDDs will be established in B02BD Blood coagulation factors. 
Refers to ampicillin 
The DDD for tiotropium bromide is unchanged but has been defined as the content of one inhalation capsule (18 mcg) as tiotropium. Since there are different inhalation capsules on the market containing different amounts of active substance, the DDD is now defined as the delivered dose, which is the same (10 mcg) as tiotropium for all products.

Last updated: 2017-01-12

Источник: Фармацевтическое обозрение Казахстана со ссылкой на редакцию "КНФ".

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